A phase 2a, randomized, double-blind, placebo-controlled, multi-site, proof of concept trial to evaluate the efficacy and safety of LEO 138559 in adult subjects with moderate to severe atopic dermatitis (AD).
Diffuse Large B-cell Lymphoma
The purpose of this clinical research study is to test the drug brentuximab vedotin combined with lenalidomide and rituximab in patients with diffuse large B-cell lymphoma (DLBCL) that did not get better or that came back after treatment compared to treatment with lenalidomide and rituximab.
A retreatment study with brentuximab vedotin in subjects with classical Hodgkin lymphoma or peripheral T cell lymphoma whose cancer got better after taking brentuximab vedotin, and subsequently got worse.
This trial will study brentuximab vedotin (BV) (Part E), to find out whether it is an effective treatment for Hodgkin Lymphoma. Patients in this study will have other conditions that make them unable to receive standard chemotherapy treatment.
This is a Phase 3 clinical study investigating the safety and efficacy of a potential treatment for participants with Myelofibrosis (MF) who have suboptimal response while receiving ruxolitinib monotherapy.
Major Depressive Disorder
The goal of the study is to evaluate the safety and effectiveness of an investigational drug compared to placebo in patients with Major Depressive Disorder.
Study to Assess the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression, Agitation, and Irritability in Patients With Traumatic Brain Injury
A Phase 2/3 Randomized, Double-blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of ADG20 in the Prevention of COVID-19 (EVADE)
This study is designed to assess the efficacy, safety and tolerability of different doses and dose regimens (every week or every 2 weeks) of BIO89-100 compared to placebo in subjects with SHTG. The study will separately evaluate the response to BIO89-100 in subjects who are not on fibrate therapy and subjects who remain on their current fibrate therapy.
An Open-Label Multiple Dose Study of RZ358 in Patients with Congenital Hyperinsulinism
|Human Metapneumovirus and Human Parainfluenza Infection|
A Human Metapneumonovirus (hMPV) and Parainfluenza Virus Type 3 (PIV3) vaccine study for children
|Carcinoma, Transitional Cell|
A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer
|Metastatic Colorectal Adenocarcinoma|
A Clinical Trial for HER2+ Metastatic Colorectal Cancer
This is a Phase 2 study to investigate the safety, tolerability, PK, and PD of ATI-450 plus methotrexate versus methotrexate alone in patients with moderate to severe RA.
A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19
|SARS-CoV Infection, Covid19|
A Study Looking at the Efficacy, Immune Response, and Safety of a COVID-19 Vaccine in Adults at Risk for SARS-CoV-2
An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Patients With High-Risk Melanoma (KEYNOTE-942)
Dose-Finding Trial to Evaluate the Safety and Immunogenicity of Cytomegalovirus Vaccine mRNA-1647 in Healthy Adults
A Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 Vaccine in Adolescents 12 to <18 Years Old to Prevent COVID-19
A Study to Evaluate Safety, Reactogenicity, and Immunogenicity of mRNA-1283 and mRNA-1273 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines in Healthy Adults Between 18 Years and 55 Years of Age
A Study of mRNA-1010 Seasonal Influenza Vaccine in Healthy Adults